Jean Despujols was born in Salles, in the Bordeaux region of France.
Despujols was a student in Bordeaux and then in Paris. In 1914 he won the prestigious Prix de Rome. He was a soldier on the front in World War One, where he did many sketches of his experiences.
Despujols exhibited at the Salon des Tuileries, Salon des Indépendants, Salon des Artistes Français. He won many prizes.